Phenylpiracetam – Review and Dosage


Phenylpiracetam (Phenotropil) belongs to a group of nootropics which feature brain enhancement and cognitive abilities. It is one of the many nootropics which have gained popularity in recent years, so this topic is worth researching. Phenylpiracetam belongs to a group of nootropics, called racetams.

They are known to have a strong influence on the brain. They increase your concentration and can help you push yourself further than you could ever go, so they are a great way to become the best version of yourself. As you will read in this article, phenylpiracetam has many benefits, including improving your cognitive abilities, reducing anxiety, enhancing your athletic abilities, and even help you in your studies.

Here are some of the most common racetams:

  • Aniracetam
  • Oxiracetam
  • Piracetam
  • Pramiracetam

You can read about the racetam group of nootropics here.

By simply adding a phenyl group to the structure of piracetam, you get phenylpiracetam. However, phenylpiracetam has been proved to be more neuroprotective than piracetam. In addition to that, it enhances physical performance and possesses psychostimulatory properties.

A fair amount of research has been conducted on the effectivity of the substance. A major part of these studies used phenylpiracetam for a month, and its benefits applied more for cases of dementia and stroke, instead of traumatic brain injury. A study conducted on rats showed signs of cognitive development (the improvement was noted in the R-isomer of phenylpiracetam).

The Structure of Phenylpiracetam

As stated in the overview, phenylpiracetam has the structure of piracetam, with the difference that it has one additional phenyl group, which is attached to the pyrrolidone nucleus. Its position contributes to it only existing in an R or S isomer.

The addition of the phenyl group, makes phenylpiracetam superior to piracetam, in fact, phenylpiracetam has been proven to be about 30 to 60 times more potent than piracetam. Also, when compared to other racetams, it is still very potent, even when used orally. Phenylpiracetam has a half-life of around 3-5 hours.

Phenylpiracetam has a close resemblance to phenylethylamine, which is known for its stimulatory effects. This may contribute to phenylpiracetam to have such high power to boost energy. The benzene ring of the phenyl group is likely responsible for increasing the affinity for neurotransmitter transporters.


It is recommended to start taking phenylpiracetam with a low dosage, and not taking other nootropics at the same time so that you can determine your sensitivity to it.

Because of the high potency of phenylpiracetam, it is recommended to take it in lower doses at the beginning, and they increase them gradually. A typical dose is around 100-200mg per dose. It is advisable not to take more than three doses per day.

Tolerance to phenylpiracetam can be developed quite fast, so it’s not recommended as much for daily usage, but is better to use it as a means to boost your abilities in times when you need them the most. You can also use it periodically. If you use it daily, you won’t experience much change after some time of using the supplement, since you would have developed a tolerance to it. If this happens, you need to stop taking the substance for a certain period of time (maybe a few months), and after that time has passed, you can continue with a more careful and sporadic use. In this way, you will be able to get the most out of it.

Benefits of using phenylpiracetam

Research has been conducted on the effect phenylpiracetam has in different aspects of the human psyche. Phenylpiracetam is shown to have more benefits in helping people with cognitive decline from organic causes. PhenylpiracetamHowever, phenylpiracetam has also been proven to protect the brain and also enhances physical performance and helps reduce stress levels. This is why phenylpiracetam has become very popular during recent years, especially among students and athletes. They have recognized its positive influence and its potential. I will list some of the results of the benefits of phenylpiracetam in various areas:

  • Cognition

Research has shown that Phenotropil has a great influence on cognition. The cognition of the test subjects who suffered from cognitive decline, epilepsy, and organic brain lesions had improved significantly by the usage of phenylpiracetam. However, there isn’t any research conducted on young and healthy subjects to compare the results.

  • Cognitive Decline

The usage of this nootropic has significantly reduced the rate of cognitive decline in the test subjects. The effects of this substance on cognition should be further researched.

  • Stroke Recovery Rate

Cognitive and physical symptoms of stroke are reduced faster with daily usage of this nootropic. The elders experienced a much more comfortable and fast recovery, aided by phenylpiracetam. This shows one of the ways in which phenylpiracetam can be used to aid older and sick people.

  • Functionality of Elderly and Injured People

Phenylpiracetam seems to benefit the functioning of these elderly people and survivors of some kind of stroke and improves their daily lives significantly. However, its influence on healthy elderly people has not been researched yet.

  • Anxiety

In addition to the previous benefits, phenylpiracetam also soothes anxiety which occurs as a symptom of a stroke. Again, there is no data on how this drug affects healthy people with anxiety.

  • Depression

The same as with anxiety, it helps with battling depression which occurs after a stroke. This is a crucial part of a person’s process of recovery from a stroke. Depression is very common among these people and should be treated carefully and researched more thoroughly. If phenylpiracetam really has a proven effect on depression, its usage should spread even among physically healthy people who are battling depression every day, and this number is growing by the hour. Phenylpiracetam can serve as a tool to fight this plague of today’s society.

  • Psychostimulation

There was a research conducted, where rats were injected with a dose (10-50mg/kg) of phenylpiracetam, and it resulted in an increase of their locomotor activity. This was mostly due to the R-isomer of phenylpiracetam. They also improved their memory. So, if it had this effect on rats, it might be worthwhile to further explore the psycho stimulative properties of phenylpiracetam. If it had this effect on rats, then the research should be expanded to humans as well. Imagine the contribution it can have on humans, especially on patients with Alzheimer’s disease in the area of memory improvement mentioned above. The opportunities are endless.

  • Memory, problem-solving skills, attention switching

Phenylpiracetam improved memory, problem-solving skills and attention switching in subjects with asthenia. Again, this could be very helpful to students who struggle in class and can help them improve their whole view on school and life in general.


  • Cold Resistance

This is a controversial effect of phenylpiracetam, and you will read about it in “Potential Side Effects”. Phenylpiracetam has the ability to reduce the effects of cold on the body by increasing the body’s tolerance to cold. This could be very useful to mountain climbers, maybe, but it is most commonly used by athletes, which is why it has become so controversial.

  • Learning and Studying

As I mentioned, phenylpiracetam has become popular among students, and this is because of its stimulating nature. Students use phenylpiracetam during long studying sessions when they remain sleep deprived. They also use it as a way to remain more focused on their studying. It also has a great influence in memory retention, so by using phenylpiracetam, the students will remember more, and preserve the material they’ve learned in their memory.

Another aspect of phenylpiracetam which aids the students is its influence on motivation and mood enhancement, which is an important part of a student’s academic life. Also, the effect of phenylpiracetam on stress reduction and anxiety suppression has a crucial role in the lives of students, since it would help them deal with studying under pressure more easily. I believe that this nootropic may prove to be most beneficial to students since it offers many areas of improvement, which will aid students in their studies.

  • Boosts Athletic Performance

Another important benefit of phenylpiracetam which should be mentioned is its ability to boost athletic performance. Even though it is banned by the World Anti-Doping Agency, it is the athlete’s choice whether or not to use phenylpiracetam as a supplement. It is recommended to use when working out at the gym, because it increases stamina, speeds up recovery time and increases the user’s endurance. Not to mention that it reduces stress, which may be a negative factor when working out.

Phenylpiracetam has been compared to amphetamine in the context it provides energy to the user in a similar way as amphetamine does. To make things better, there isn’t a significant crash after the effect wears off.

Phenylpiracetam Potential Side Effects

There are a few side effects if you use the correct dosage for phenylpiracetam, as it is for all the other racetams. The most common one is headaches. If you experience this side effect, you should take it as a sign to lower or increase your chlorine intake. Apart from headaches, there have also been reported some sleep disturbances after the usage of the substance.

I should note that each person has a unique body which will react somewhat differently, so you should be careful with which supplements you take, and the amount of the dosage. Some people might experience discomfort and negative side effects by not taking the right dosage, this means taking too much of the supplement. These side effects include vertigo, nausea, insomnia, and anxiety. Please contact a doctor if you experience more severe negative side effects.

Due to its psychostimulatory effect and cold resistance properties, the substance is banned by the World Anti-Doping Agency.

You may need a prescription in order to purchase racetams since they are synthesized drugs and are different from dietary supplements. Also, the fact that they aren’t fully researched yet contributes to them getting this reputation.


These side effects are insignificant compared to the opportunities this nootropic substance has to offer. It is still a relatively new supplement but has gained a lot of recognition in the past few years. I believe that its use will be mainly focused on athletics and education. However, its influence on cognition is very important and should be further developed, since it has the ability to help many people through hard times in their lives.

Nootropics might be the future of human civilization, they open many doors and opportunities for us, and we should take the opportunity and use it to our advantage. The appearance of many supplements during the last couple of years only shows humanity’s will to improve and try to push the limits of our biology. We shouldn’t be scared of this; we should embrace it. This is the future.

Even though nootropics have a shady reputation, for now, it won’t be long until people realize what contribution nootropics can make in our civilization.